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8-oxo-Guo and polyU stimulate inflammation via NLR and TLR signaling pathways. (A, B) Transcriptome analysis of MH-S cells following 2-h stimulation with 8-oxo-Guo and/or polyU. (A) KEGG pathway enrichment analysis. (B) GSEA. (C) Relative mRNA expression levels of NOD2 , TLR2 , and <t>NLRP3</t> in cells after 2-h stimulation with 8-oxo-Guo and/or polyU. ∗ p < 0.05, ∗∗ p < 0.01, ∗∗∗ p < 0.001. (D) Protein expression changes and grayscale quantification of key components of NLR, TLR, MAPK, JAK-STAT, and NF-κB signaling pathways following 2-h stimulation with 8-oxo-Guo and/or polyU. ∗ p < 0.05, ∗∗ p < 0.01, ∗∗∗ p < 0.001.
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8-oxo-Guo and polyU stimulate inflammation via NLR and TLR signaling pathways. (A, B) Transcriptome analysis of MH-S cells following 2-h stimulation with 8-oxo-Guo and/or polyU. (A) KEGG pathway enrichment analysis. (B) GSEA. (C) Relative mRNA expression levels of NOD2 , TLR2 , and <t>NLRP3</t> in cells after 2-h stimulation with 8-oxo-Guo and/or polyU. ∗ p < 0.05, ∗∗ p < 0.01, ∗∗∗ p < 0.001. (D) Protein expression changes and grayscale quantification of key components of NLR, TLR, MAPK, JAK-STAT, and NF-κB signaling pathways following 2-h stimulation with 8-oxo-Guo and/or polyU. ∗ p < 0.05, ∗∗ p < 0.01, ∗∗∗ p < 0.001.
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8-oxo-Guo and polyU stimulate inflammation via NLR and TLR signaling pathways. (A, B) Transcriptome analysis of MH-S cells following 2-h stimulation with 8-oxo-Guo and/or polyU. (A) KEGG pathway enrichment analysis. (B) GSEA. (C) Relative mRNA expression levels of NOD2 , TLR2 , and <t>NLRP3</t> in cells after 2-h stimulation with 8-oxo-Guo and/or polyU. ∗ p < 0.05, ∗∗ p < 0.01, ∗∗∗ p < 0.001. (D) Protein expression changes and grayscale quantification of key components of NLR, TLR, MAPK, JAK-STAT, and NF-κB signaling pathways following 2-h stimulation with 8-oxo-Guo and/or polyU. ∗ p < 0.05, ∗∗ p < 0.01, ∗∗∗ p < 0.001.
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8-oxo-Guo and polyU stimulate inflammation via NLR and TLR signaling pathways. (A, B) Transcriptome analysis of MH-S cells following 2-h stimulation with 8-oxo-Guo and/or polyU. (A) KEGG pathway enrichment analysis. (B) GSEA. (C) Relative mRNA expression levels of NOD2 , TLR2 , and NLRP3 in cells after 2-h stimulation with 8-oxo-Guo and/or polyU. ∗ p < 0.05, ∗∗ p < 0.01, ∗∗∗ p < 0.001. (D) Protein expression changes and grayscale quantification of key components of NLR, TLR, MAPK, JAK-STAT, and NF-κB signaling pathways following 2-h stimulation with 8-oxo-Guo and/or polyU. ∗ p < 0.05, ∗∗ p < 0.01, ∗∗∗ p < 0.001.

Journal: Redox Biology

Article Title: 8-oxo-7,8-dihydroguanosine (8-oxo-Guo) drives pulmonary inflammatory pathways through pattern recognition receptors

doi: 10.1016/j.redox.2026.104211

Figure Lengend Snippet: 8-oxo-Guo and polyU stimulate inflammation via NLR and TLR signaling pathways. (A, B) Transcriptome analysis of MH-S cells following 2-h stimulation with 8-oxo-Guo and/or polyU. (A) KEGG pathway enrichment analysis. (B) GSEA. (C) Relative mRNA expression levels of NOD2 , TLR2 , and NLRP3 in cells after 2-h stimulation with 8-oxo-Guo and/or polyU. ∗ p < 0.05, ∗∗ p < 0.01, ∗∗∗ p < 0.001. (D) Protein expression changes and grayscale quantification of key components of NLR, TLR, MAPK, JAK-STAT, and NF-κB signaling pathways following 2-h stimulation with 8-oxo-Guo and/or polyU. ∗ p < 0.05, ∗∗ p < 0.01, ∗∗∗ p < 0.001.

Article Snippet: The NOD2 inhibitor GSK717 (HY-136555) and NLRP3 inhibitor MCC950 (HY-12815A) were obtained from MedChemExpress (MCE), and the TLR2 inhibitor Cu-CPT22 (S8677) was obtained from Selleck.

Techniques: Protein-Protein interactions, Expressing

Dose-dependent suppression of 8-oxo-Guo/polyU-induced inflammation upon NOD2, TLR2, and NLRP3 inhibition. (A-F) Protein expression changes in NLR, TLR, and downstream signaling pathways (left panels) and concentrations of TNF-α, MIP-2, IL-1β, and MCP-1 in the culture supernatant (right panels) of MH-S cells following 4-h co-stimulation with 8-oxo-Guo and polyU in the presence of GSK717 (A, B) , Cu-CPT22 (C, D) , or MCC950 (E, F) . ∗∗ p < 0.01, ∗∗∗ p < 0.001. (G, H) Protein expression profiles of relevant signaling pathways (G) and cytokine concentrations in the culture supernatant (H) of MH-S cells that were treated for 4 h with 8-oxo-Guo and polyU combined with GSK717, Cu-CPT22, or MCC950, either individually or combined. ∗ p < 0.05, ∗∗ p < 0.01, ∗∗∗ p < 0.001.

Journal: Redox Biology

Article Title: 8-oxo-7,8-dihydroguanosine (8-oxo-Guo) drives pulmonary inflammatory pathways through pattern recognition receptors

doi: 10.1016/j.redox.2026.104211

Figure Lengend Snippet: Dose-dependent suppression of 8-oxo-Guo/polyU-induced inflammation upon NOD2, TLR2, and NLRP3 inhibition. (A-F) Protein expression changes in NLR, TLR, and downstream signaling pathways (left panels) and concentrations of TNF-α, MIP-2, IL-1β, and MCP-1 in the culture supernatant (right panels) of MH-S cells following 4-h co-stimulation with 8-oxo-Guo and polyU in the presence of GSK717 (A, B) , Cu-CPT22 (C, D) , or MCC950 (E, F) . ∗∗ p < 0.01, ∗∗∗ p < 0.001. (G, H) Protein expression profiles of relevant signaling pathways (G) and cytokine concentrations in the culture supernatant (H) of MH-S cells that were treated for 4 h with 8-oxo-Guo and polyU combined with GSK717, Cu-CPT22, or MCC950, either individually or combined. ∗ p < 0.05, ∗∗ p < 0.01, ∗∗∗ p < 0.001.

Article Snippet: The NOD2 inhibitor GSK717 (HY-136555) and NLRP3 inhibitor MCC950 (HY-12815A) were obtained from MedChemExpress (MCE), and the TLR2 inhibitor Cu-CPT22 (S8677) was obtained from Selleck.

Techniques: Inhibition, Expressing, Protein-Protein interactions